Nucleotide modification is a research area in molecular biology that focuses on the chemical modification of nucleotides, the building blocks of DNA and RNA molecules. These modifications can alter the structure, stability, and function of nucleic acids, as well as influence important cellular processes such as gene expression, protein synthesis, and DNA repair. Nucleotide modifications can occur through various mechanisms, including enzymatic processes and environmental factors, and can have significant implications for health and disease. Research in this area seeks to understand the biological roles of nucleotide modifications, develop methods for their detection and analysis, and explore their potential applications in fields such as diagnostics, therapeutics, and biotechnology.